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SYNERA® Savings Program

Stop the Sting of Needle-Stick Pain

Jennifer’s IVF Story

My husband and I went through five cycles of a very aggressive IVF regimen. In one particular cycle, three weeks after the embryos were transferred, my doctor said we needed to start doing daily blood monitoring. During that time, my veins became very rolly—all of a sudden, I went from being an easy stick for blood monitoring to being this horrible stick.

When a friend saw how much difficulty I was having, she showed me a SYNERA® patch that her child was using for needle sticks and suggested I ask my doctor about getting a prescription. So I did, and the doctor ordered SYNERA® for me.

I tried it. And it really changed how I felt about my IVF treatment.

With SYNERA®, getting needle sticks wasn’t as painful.

I could put the SYNERA® patch on at home, and by the time I got to my appointment, the area was numb and they could stick me right away. It made me a much easier stick, and, if God forbid, I had to be stuck more than once, I wasn’t stressing about the pain.

I’m telling you, the SYNERA® patch really eased the journey to having my daughter. And if I wanted to try for another baby—even with all of the blood work—I could do it all over again with SYNERA®.


Kelsey’s IVF Story

Getting assistance with fertility is such a hard journey for so many reasons. I’m not a fan of needle sticks, but you understand that you’re going to have to go through the pain in order hopefully to have a positive outcome. So you go through it.

As part of everything else that I ordered, my fertility clinic had me order SYNERA® to help prevent needle stick pain. With the manufacturer co-pay program, the patches were reasonably priced. And, honestly, I would be willing to pay hundreds of dollars for them once I saw for myself how well they worked.

The SYNERA® patch took away a lot of the pain I would have had otherwise.

The instructions made it very clear how to use the patch, and it was really easy to remove before getting a needle stick. When I used the patch, I knew that the needle stick wasn’t going to hurt. And knowing what to expect just helped me stay calm through the process.

SYNERA® made going through my fertility journey much more bearable.


No adequate and well-controlled studies have been conducted in pregnant women. SYNERA® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.1

In clinical studies involving 1,449 subjects treated with SYNERA®, the most common local reactions were redness of the skin (71%), pale skin (12%) and swelling (12%); these reactions were generally mild and resolved on their own soon after patch removal. There were no treatment related serious adverse events.1


  1. SYNERA® Prescribing Information. Galen US Inc., Souderton, PA; November 2018.
  2. Masud S, Wasnich RD, Ruckle JL, et al. Contribution of a heating element to topical anesthesia patch efficacy prior to vascular access: results from two randomized, double-blind studies. J Pain Symptom Manage. 2010;40(4):510-519.
  3. Lidocaine 2.5% and Prilocaine 2.5% Cream Prescribing Information. Akorn Inc., Lake Forest, IL; February 2013.
  4. Wallace MS, Kopecky EA, Ma T, Brophy F, Campbell JC. Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (SYNERA®) patches compared with placebo patches applied to healthy adult volunteers. Reg Anesth Pain Med. 2010;35(6):507-513.
  5. Sethna NF, Verghese ST, Hannallah RS, Solodiuk JC, Zurakowski D, Berde CB. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005;102(2):403-408.
  6. Sawyer J, Febbraro S, Masud S, Ashburn MA, Campbell JC. Heated lidocaine/tetracaine patch (SYNERA®, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access. Br J Anaesth. 2009;102(2):210-215.


SYNERA® (lidocaine and tetracaine) Topical Patch is indicated for use on unbroken skin to help prevent the pain of needle sticks into superficial veins (apply for 20-30 mins) and some superficial skin procedures (apply for 30 mins).

Important Safety Information

SYNERA® is not to be used in patients with a known history of sensitivity to lidocaine, tetracaine, numbing medications of the amide or ester type, or any other component of the product and in patients with para-aminobenzoic acid (PABA) hypersensitivity.

Keeping a patch on longer than recommended or applying multiple patches at the same time or one right after the other could result in absorption of sufficient amounts of drug to result in serious adverse effects.

Patients should not use SYNERA® if they have a history of methemoglobinemia. If SYNERA® must be used in patients who are more susceptible to developing the condition, they should be closely monitored for signs and symptoms, which may occur immediately or may be delayed some hours, and must be treated immediately. SYNERA® and any other drugs which can increase the risk of developing methemoglobinemia should be discontinued.

Used SYNERA® patches contain a large amount of lidocaine and tetracaine (at least 90% of the initial amount). Chewing or swallowing a new or used SYNERA® patch may result in serious adverse effects. Store and dispose of SYNERA® out of the reach of children and pets.

SYNERA® should be used with caution in patients who may be more sensitive to the general effects on the body of lidocaine and tetracaine, particularly those who are seriously ill or weakened by illness, and those with reduced liver function. Patients with severe liver disease or missing adequate blood plasma enzymes are at greater risk of developing toxic plasma concentrations.

Do not use on body passages such as inside the nose or mouth or on areas with unhealthy, broken skin.

Application to broken or inflamed skin may result in toxic blood concentrations of lidocaine and tetracaine.

Allergic or extreme sensitivity (skin rash, swelling or hives, narrowing of airways, and shock) to the active or inactive components of SYNERA® can occur and should be managed by a medical professional. Seek immediate emergency help if any of these occur.

Avoid contact of SYNERA® with the eyes due to potential irritation or abrasion. If contact occurs, immediately wash out the eye with water or saline, and protect it until sensation returns.

The application of more than two SYNERA® patches at the same time or one right after another to children is not recommended as it has not been fully studied. Safety and effectiveness of SYNERA® have been established in patients 3 years of age and older.

Lidocaine, one of the numbing medications in SYNERA®, has been shown to prevent the growth of viruses and bacteria. The effect of SYNERA® on needle sticks into the skin for certain vaccines has not been determined.

The heating component contains iron powder, and the patch must be removed before some diagnostic procedures, including magnetic resonance imaging (MRI).

SYNERA® may lead to little or no feeling in the area of the skin where it is applied; therefore, patients should avoid trauma (rubbing, scratching, or exposure to heat or cold) before complete feeling returns.

SYNERA® should be used with caution in patients receiving certain heart medications and/or other local pain-preventing medications, because there may be additional toxic effects with lidocaine and tetracaine.

In clinical studies involving 1,449 subjects treated with SYNERA®, the most common local reactions were redness of the skin (71%), pale skin (12%) and swelling (12%); these reactions were generally mild and resolved on their own soon after patch removal. There were no treatment related serious adverse events.1

SYNERA® should be applied immediately after opening the pouch. Do not cut or remove the top cover of the patch as this could result in a burn injury.

If skin irritation or a burning sensation occurs during application, remove the patch and inform your doctor or nurse immediately.

Please see Full Prescribing Information including Instructions For Use before using SYNERA®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.