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Do you hate when the doctor or nurse has to stick your child with a needle? Doctors, nurses, parents, and other caregivers don’t like to see a child in discomfort and pain, but sometimes it is necessary for the health of the child. The good news is that there is a way to help prevent needle-stick pain…just ask your child’s doctor or nurse about SYNERA®.

SYNERA® is a prescription medication that is fast and effective and helps prevent needle-stick pain. The only way you can get SYNERA® for your child is by prescription or from their doctor or nurse. Ask the doctor or nurse about SYNERA® and how it can help you all get through medical tests, procedures, and treatment more easily by helping to prevent needle-stick pain.


Making SYNERA® Available with the Galen Access Program


Order SYNERA® with our pharmacy partner–Transition Pharmacy

Patient advocates can conduct benefits investigations, answer insurance questions, administer the Co-pay Savings Program, and arrange for shipment of SYNERA® at the best price directly to your home.

If your child’s doctor has decided that SYNERA® is right for your child, the required forms can be downloaded below for printing:

  • Complete and sign the Enrollment Form
  • Your child’s doctor will fax the form and prescription
  • The patient advocate will call you to assist with insurance questions and shipment of SYNERA® directly to you

Call with any questions: 1-844-GALENRX (1-844-425-3679).


Retail pharmacies

SYNERA® prescriptions can be filled at your preferred retail pharmacy. Your child’s doctor will provide you with the SYNERA® Co-pay Savings Program information along with the SYNERA® prescription.


Specialty pharmacies

Ensure your specialty pharmacy has the SYNERA® Co-pay Savings Program card for all SYNERA® prescriptions. Download a copy of the Co-pay card at the link below.

Making SYNERA® Affordable with the Galen Access Program

Savings programs or co-pay programs are available with the Galen Access Program.

Patients Can Save, With or Without Coverage

Please note that this offer cannot be redeemed by patients eligible for Medicare (including Medicare Advantage or Part D prescription drug plans), Medicaid, or other public payment programs.

Talk to your healthcare provider about the SYNERA® Co-pay Savings Program and see if it’s right for you and your child.

In clinical studies involving 1,449 subjects treated with SYNERA®, the most common local reactions were redness of the skin (71%), pale skin (12%) and swelling (12%); these reactions were generally mild and resolved on their own soon after patch removal. There were no treatment related serious adverse events.1


  1. SYNERA® Prescribing Information. Galen US Inc., Souderton, PA; November 2018.
  2. Masud S, Wasnich RD, Ruckle JL, et al. Contribution of a heating element to topical anesthesia patch efficacy prior to vascular access: results from two randomized, double-blind studies. J Pain Symptom Manage. 2010;40(4):510-519.
  3. Lidocaine 2.5% and Prilocaine 2.5% Cream Prescribing Information. Akorn Inc., Lake Forest, IL; February 2013.
  4. Wallace MS, Kopecky EA, Ma T, Brophy F, Campbell JC. Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (SYNERA®) patches compared with placebo patches applied to healthy adult volunteers. Reg Anesth Pain Med. 2010;35(6):507-513.
  5. Sethna NF, Verghese ST, Hannallah RS, Solodiuk JC, Zurakowski D, Berde CB. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. Anesthesiology. 2005;102(2):403-408.
  6. Sawyer J, Febbraro S, Masud S, Ashburn MA, Campbell JC. Heated lidocaine/tetracaine patch (SYNERA®, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access. Br J Anaesth. 2009;102(2):210-215.


SYNERA® (lidocaine and tetracaine) Topical Patch is indicated for use on unbroken skin to help prevent the pain of needle sticks into superficial veins (apply for 20-30 mins) and some superficial skin procedures (apply for 30 mins).

Important Safety Information

SYNERA® is not to be used in patients with a known history of sensitivity to lidocaine, tetracaine, numbing medications of the amide or ester type, or any other component of the product and in patients with para-aminobenzoic acid (PABA) hypersensitivity.

Keeping a patch on longer than recommended or applying multiple patches at the same time or one right after the other could result in absorption of sufficient amounts of drug to result in serious adverse effects.

Patients should not use SYNERA® if they have a history of methemoglobinemia. If SYNERA® must be used in patients who are more susceptible to developing the condition, they should be closely monitored for signs and symptoms, which may occur immediately or may be delayed some hours, and must be treated immediately. SYNERA® and any other drugs which can increase the risk of developing methemoglobinemia should be discontinued.

Used SYNERA® patches contain a large amount of lidocaine and tetracaine (at least 90% of the initial amount). Chewing or swallowing a new or used SYNERA® patch may result in serious adverse effects. Store and dispose of SYNERA® out of the reach of children and pets.

SYNERA® should be used with caution in patients who may be more sensitive to the general effects on the body of lidocaine and tetracaine, particularly those who are seriously ill or weakened by illness, and those with reduced liver function. Patients with severe liver disease or missing adequate blood plasma enzymes are at greater risk of developing toxic plasma concentrations.

Do not use on body passages such as inside the nose or mouth or on areas with unhealthy, broken skin.

Application to broken or inflamed skin may result in toxic blood concentrations of lidocaine and tetracaine.

Allergic or extreme sensitivity (skin rash, swelling or hives, narrowing of airways, and shock) to the active or inactive components of SYNERA® can occur and should be managed by a medical professional. Seek immediate emergency help if any of these occur.

Avoid contact of SYNERA® with the eyes due to potential irritation or abrasion. If contact occurs, immediately wash out the eye with water or saline, and protect it until sensation returns.

The application of more than two SYNERA® patches at the same time or one right after another to children is not recommended as it has not been fully studied. Safety and effectiveness of SYNERA® have been established in patients 3 years of age and older.

Lidocaine, one of the numbing medications in SYNERA®, has been shown to prevent the growth of viruses and bacteria. The effect of SYNERA® on needle sticks into the skin for certain vaccines has not been determined.

The heating component contains iron powder, and the patch must be removed before some diagnostic procedures, including magnetic resonance imaging (MRI).

SYNERA® may lead to little or no feeling in the area of the skin where it is applied; therefore, patients should avoid trauma (rubbing, scratching, or exposure to heat or cold) before complete feeling returns.

SYNERA® should be used with caution in patients receiving certain heart medications and/or other local pain-preventing medications, because there may be additional toxic effects with lidocaine and tetracaine.

In clinical studies involving 1,449 subjects treated with SYNERA®, the most common local reactions were redness of the skin (71%), pale skin (12%) and swelling (12%); these reactions were generally mild and resolved on their own soon after patch removal. There were no treatment related serious adverse events.1

SYNERA® should be applied immediately after opening the pouch. Do not cut or remove the top cover of the patch as this could result in a burn injury.

If skin irritation or a burning sensation occurs during application, remove the patch and inform your doctor or nurse immediately.

Please see Full Prescribing Information including Instructions For Use before using SYNERA®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.